1. Mechanistic insights into the islet-intrinsic mechanisms that control CFTR-dependent insulin secretion
2. Understanding of the role of CFTR channel function in non-β-cells and the impact of CFTR mutation on insulin homeostasis
3. Mechansitic insights into the role of normal and mutant CFTR in islet cell development and signaling
4. Understanding of the role of β-cell dedifferentiation in CFRD pathogenesis
5. Elucidation of the role of exocrine inflammation in the development of endocrine dysfunction

UK CF Trust Grant Code: Strategic Research Centre 007