1. A detailed understanding of the prevalence, risk factors, spectrum and impact of joint disease in patients with CF.
2. Development of a systematic classification of joint disease in CF
3. Establish the role of ultrasound in identifying joint inflammation in CFA and its correlation with systemic inflammation.
4. Determine the roles of TLR-mediated XBP1 activation and Ca(2+) mediated NLRP3 inflammasome activation in CF and CFA.
5. Determine the roles of IL-1 activity in CF and CFA and provide evidence to support a therapeutic trial of anti-IL-1.

UK CF  Trust Grant Code: Strategic Research Centre 009