|Project name:||Project category:||Kind of research:||Country:||Principle investigator:|
Natural Killer immunity during CMV infection in the context of lung transplantation
Background : Lung transplantation remains the only curative therapeutic option of the end stage respiratory diseases such as cystic fibrosis, chronic obstructive pulmonary disease, pulmonary fibrosis. However, lung transplant mortality remains high (survival is 68% after one year post transplantation) and is mainly depending on acute and chronic rejection, and opportunistic infections like CMV infection. Before the CMV prophylaxis era, CMV infection could lead to very severe graft injuries. In solid organ transplantation, epidemiological associations have been established between the occurrence of acute and/or chronic rejection and CMV infection. However, the reason for this association remains unclear.
Methods: In order to test this hypothesis, we plan to perform a comprehensive study of CMV responsiveness in lung transplant recipient (n=46) followed in Foch Hospital (Paris). Longitudinal analysis of NK responses will be performed over 24 months after lung transplantation in peripheral blood, broncho-alveolar lavage (BAL) and lung tissues. Patients have been categorized according to the CMV serostatus of the donor/recipient pairs. All the samples and clinical data are available.
Objectives & Expected results: While anti-CMV T-cell immunity is important to prevent the development of CMV related disease, it could also have adverse effects at the level of the transplanted lungs, by affecting the balance between the transplant and its host towards acute rejection. Our aim is to get insights into the relationship between CMV infection and acute rejection, which is important to optimize the immunosuppressive and prophylactic treatments of transplanted patients.
|Project amount (€):||53.000|