|Project name:||Project category:||Kind of research:||Country:||Principle investigator:|
Implication of miRNA in CF lung pathology: Studies of inflammation and ANO1 regulation by miRNAs
Cystic fibrosis (CF) is an autosomal recessive disorder due to mutations in the CF transmembrane conductance regulator (CFTR) gene. These mutations cause impaired airway epithelial cell CFTR channels, loss of airway surface liquid, reduced mucus clearance, recurrent infection and chronic inflammation.
Despite the prominent role of inflammation in a wide range of diseases, little is known about its regulation and influence on the human lung epithelial cell. We well known that NFkB and MAP kinases pathway are involved but the origin of this induction remain unknown.
So, we proposed to analyse one aspect of epigenetic to regulate proteins by miRNA analysis.
The aims of this study is to analyse:
This study will help to define the regulation and complex biology of some genes/proteins and in airway epithelium of patients with CF. This project will be an extensive miRNA study in the context of CF.
|Project amount (€):||50.000|