Project name: Project category: Kind of research: Country: Principle investigator:

HIT CF 2.0

New Therapies
CFTR
Clinical research Netherlands Prof. Kors van der Ent
Start date: 01/01/2017
End date: 31/12/2021
Status: Ongoing
Abstract:

The goal of HIT CF 2.0 is to prepare a future in which all people with cystic fibrosis can get access to a treatment tackling the cause of CF. HIT CF 2.0 builds on the novel techniques and treatments that were explored during the initial HIT CF-program and that should enable individualised therapy. They will now be improved and applied.

HIT CF 2.0 was initiated by the Dutch CF Foundation and the UMC Utrecht in cooperation with researchers and clinicians from Rotterdam. The research project is endorsed by all CF centers and the Dutch CF Foundation community advisory board composed of patients and parents. On a national level, there is a cooperation between all CF centers and internationally with researchers from Leuven and Lisbon.

The research program is composed of 17 smaller projects which can be organised in 4 aims:

1/ Predict

To confirm the capacity of organoids and measurement in airway cells to predict the effects of individualised therapy.

2/ Apply

To apply the organoids for individualised medicine.

3/ Develop

To develop and apply sensitive measuring methodes to evaluate the functionality of the chloride channels and the effects of novel therapies.

4/ Innovate

To further unravel the disease mechanism of CF to develop novel methods to improve the functioning of the chloride channel.

 

 

 

 

Website URL: https://www.ncfs.nl/onderzoek/lopend/hitcf
Project amount (€): 5.000.000

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