|Project name:||Project category:||Kind of research:||Country:||Principle investigator:|
HIT CF 2.0
|Clinical research||Netherlands||Prof. Kors van der Ent|
The goal of HIT CF 2.0 is to prepare a future in which all people with cystic fibrosis can get access to a treatment tackling the cause of CF. HIT CF 2.0 builds on the novel techniques and treatments that were explored during the initial HIT CF-program and that should enable individualised therapy. They will now be improved and applied.
HIT CF 2.0 was initiated by the Dutch CF Foundation and the UMC Utrecht in cooperation with researchers and clinicians from Rotterdam. The research project is endorsed by all CF centers and the Dutch CF Foundation community advisory board composed of patients and parents. On a national level, there is a cooperation between all CF centers and internationally with researchers from Leuven and Lisbon.
The research program is composed of 17 smaller projects which can be organised in 4 aims:
To confirm the capacity of organoids and measurement in airway cells to predict the effects of individualised therapy.
To apply the organoids for individualised medicine.
To develop and apply sensitive measuring methodes to evaluate the functionality of the chloride channels and the effects of novel therapies.
To further unravel the disease mechanism of CF to develop novel methods to improve the functioning of the chloride channel.
|Project amount (€):||5.000.000|