Project name: Project category: Kind of research: Country: Principle investigator:

Exploratory studies to investigate the effect of RPL554 in primary airway cells

Genetics
Cell Biology
Basic research United Kingdom Dr. Katherine Banner
Status: Ongoing
Abstract:

1) demonstrate that RPL554 activates CFTR;
2) establish whether RPL554 can activate CFTR in R117H cells;
3) establish whether RPL554 can stimulate cilliary beat frequency in primary airway epithelial cells;
4) evaluate te role of the actin cystoskeleton using electrophysiology and fluorescence imaging and effect of RPL554 on spontaneous IL-8 release from CF airway epithelial cells

UK CF Trust Grant Code: Venture and Innovation Award 010

Institute: University of Cardiff
City: Cardiff (Wales)
Project amount (€): 74.100

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