Project name: Project category: Kind of research: Country: Principle investigator:

Efflux as a mechanism of intrinsic and acquired resistance to antibiotics in Achromobacter xylosoxidans

Infection
Antibiotics
Basic research Belgium Prof. Dr. Françoise Van Bambeke
Start date: 01/07/2017
End date: 30/06/2020
Status: Ongoing
Abstract:

Patients with cystic fibrosis often suffer from respiratory infections caused by bacteria that do not infect
other people. One of these bacteria is Achromobacter xylosoxidans. The medical doctors do therefore
not have a huge experience in the way to treat these infections, as many of the antibiotics available
today have not been developed for an activity against this type of bacteria.
One of the reasons why Achromobacter xylosoxidans poorly responds to antibiotics is the fact that it
expresses efflux transporters, i.e. proteins that can expel the antibiotics out of the bacteria, making
these drugs inactive.
The project therefore aims at studying in details the role of efflux in resistance of Achromobacter
xylosoxidans to antibiotics to better understand how it affects the response of the patient to the
treatment received.
This work will allow us to propose new diagnostic tests that will help the laboratory to better
characterize resistance in bacteria, and possibly also new treatment recommendations for these
infections.

Institute: Université Catholique de Louvain
Department: Department of Pharmaceutical Sciences, Louvain Drug Research Institute, Cellular and Molecular Pharmacology Unit
City: Brussels
Project amount (€): 220.000

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