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Project name:	Project category:	Kind of research:	Country:	Principle investigator:
OligoGpivotalCF	New Therapies	Clinical research	Europe

Start date:	01/01/2018
End date:	31/12/2020
Website URL:	Click here to visit website
Status:	Ongoing
Project amount (€):	6.000.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
HIT-CF Europe	New Therapies CFTR	Clinical research	Europe	Prof. Kors van der Ent

Start date:	01/01/2018
End date:	31/12/2022
Website URL:	Click here to visit website
Status:	Ongoing
Project amount (€):	6.700.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
MyCyFAPP	Gastroenterology-Liver	Other	Europe

Website URL:	Click here to visit website
Status:	Ongoing
Perspective:	EXPECTED OUTCOMES 1. Health and nutritional status improvement through a precise enzyme dosage. 2. Improved Quality of life both for patients and their families. 3. Economic savings both for the health system and for the patients’ families.
Project amount (€):	5.087.507

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
HIT CF 2.0	New Therapies CFTR	Clinical research	Netherlands	Prof. Kors van der Ent

Start date:	01/01/2017
End date:	31/12/2021
Website URL:	Click here to visit website
Status:	Ongoing
Project amount (€):	5.000.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Dynamics of cystic fibrosis airway microbiota: application of next-generation sequencing in a long-term cohort study to characterize bacterial and viral components prior to and during acute exacerbations	Infection	Basic research	Belgium	Prof. Dr. Lieven Dupont & Prof. Dr. Marc Van Ranst

Start date:	01/07/2017
End date:	30/06/2020
Status:	Ongoing
Institute:	KU Leuven
Department:	Department of Pneumology & Rega Institute for Medical Research
City:	Leuven
Project amount (€):	150.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Developing a personalized approach for antimicrobial susceptibility testing	Antibiotics Infection	Clinical research	Belgium	Dr. Tom Coenye

Start date:	01/07/2017
End date:	30/06/2020
Status:	Ongoing
Institute:	University of Ghent
City:	Ghent
Project amount (€):	246.500

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
The endothelium as the central mediator of cystic fibrosis-associated liver disease	Gastroenterology-Liver Pathogenesis	Basic research	Belgium	Prof. Dr. Peter Witters

Start date:	01/07/2017
End date:	30/06/2020
Status:	Ongoing
Institute:	KU Leuven
City:	Leuven
Project amount (€):	275.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Development of CFTR-stabilizers as therapeutics for cystic fibrosis	New Therapies CFTR	Basic research	Belgium	Dr. Cédric Govaerts

Start date:	01/07/2017
End date:	30/06/2020
Status:	Ongoing
Institute:	Université Libre de Bruxelles
City:	Brussels
Project amount (€):	197.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Efflux as a mechanism of intrinsic and acquired resistance to antibiotics in Achromobacter xylosoxidans	Infection Antibiotics	Basic research	Belgium	Prof. Dr. Françoise Van Bambeke

Start date:	01/07/2017
End date:	30/06/2020
Status:	Ongoing
Institute:	Université Catholique de Louvain
Department:	Department of Pharmaceutical Sciences, Louvain Drug Research Institute, Cellular and Molecular Pharmacology Unit
City:	Brussels
Project amount (€):	220.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Development of drug based therapies to target rare mutations causing severe cystic fibrosis	New Therapies CFTR	Basic research	Belgium	Dr. Marianne Carlon

Start date:	01/07/2017
End date:	30/06/2020
Status:	Ongoing
Institute:	KU Leuven
City:	Leuven
Project amount (€):	200.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Development of immuno-assays to diagnose infection with atypical mycobacteria in patients with CF and investigation of their potential role for monitoring treatment success	Infection Immunology-Inflammation	Clinical research	Belgium	Prof. Dr. Françoise Mascart

Start date:	01/07/2017
End date:	30/06/2020
Status:	Ongoing
Institute:	Université Libre de Bruxelles
City:	Brussels
Project amount (€):	220.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Intravenous Colistin use in Cystic Fibrosis patients: Pilot study of pharmacokinetics, pharmacodynamics, tolerance profile and risk of selection of resistance	Antibiotics	Clinical research	Belgium	Prof. Dr. Christiane Knoop

Start date:	01/01/2017
End date:	31/12/2018
Status:	Ongoing
Researcher:	Prof. Dr. Frederic Cotton, Prof. Dr. Olivier Denis, Dr. Maya Hites, Dr. Jean Michel Hougardy
Institute:	Hôpital Erasme (Université Libre de Bruxelles)
City:	Brussels
Project amount (€):	150.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
The relationship between socioeconomic determinants and clinical processes on disease outcomes amongst people with CF in Belgium	Other Issues	Psychosocial	Belgium	Prof. Dr. Anne Malfroot, Simeon Situma Wanyama

Start date:	01/05/2018
End date:	30/04/2020
Status:	Ongoing
Institute:	Vrije Universiteit Brussel, Sciensano
Department:	Department of Public Health
City:	Brussels
Project amount (€):	102.816

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Coping styles and adherence to treatment in adolescent, adult and transplanted patients with CF	Psychological issues	Psychosocial	Belgium	Dr. Trudy Havermans

Start date:	01/07/2014
End date:	30/06/2016
Status:	Finished
Researcher:	Dr. Trudy Havermans, Prof. Dr. Marijke Proesmans, Prof. Dr. Lieven Dupont, Prof. Dr. Robin Vos
Institute:	UZ Leuven
City:	Leuven
Project amount (€):	14.940

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Evaluation of the efficacy of novel antibacterial therapies for Pseudomonas aeruginosa biofilm eradication from airways of CF patients by using the ex vivo sputum biofilm model (EVSM)	New Therapies Microbiology	Clinical research	Belgium	Prof. Dr. Mario Vaneechoutte, Prof. Dr. Frans De Baets

Start date:	01/10/2014
End date:	31/03/2016
Status:	Finished
Researcher:	Leen Van Simaey, Dr. Sabine Van Daele, Dr. Petra Schelstraete, Marleen Vanderkerken, Ann Raman, Linda Mahieu
Institute:	University of Ghent
Department:	Department of Microbiology - Laboratory Bacteriology Research (LBR), Faculty of Medicine & Health Sciences - MucoGent (CF Reference Center)
City:	Gent
Project amount (€):	100.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Evaluation of STAT3 inhibitors as agents to increase CFTR gene expression and CFTR mediated residual chloride secretion	Cell Biology CFTR		Germany	Dr. Frauke Stanke

Start date:	04/04/2016
End date:	31/01/2018
Status:	Finished
Institute:	Medical School Hannover
Department:	Department of Pediatrics
City:	Hannover
Project amount (€):	17.800

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Restoring mutant CFTR function with nanobodies	Cell Biology New Therapies	Basic research	Belgium	Dr. Cedric Govaerts

Start date:	01/07/2012
End date:	31/03/2017
Status:	Finished
Researcher:	Dr. Jan Steyaert (Brussels, Belgium), Prof. Dr. John R. Riordan (Chapel Hill - USA), Prof. Dr. Marcus Mall (Heidelberg - Germany)
Institute:	Université Libre de Bruxelles
Department:	Structure and Function of Biological Membranes (SFMB)
City:	Brussels (Belgium)
Project amount (€):	189.300

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Prevalence and characterization of azole-resistant Aspergillus fumigatus in German CF patients	Infection Microbiology	Clinical research	Germany	Dr. Jörg Steinmann

Start date:	01/03/2015
End date:	31/08/2016
Status:	Finished
Institute:	University Hospital Essen
Department:	Institute of Medical Microbiology
City:	Essen
Project amount (€):	17.852

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
The half-lives of neutrophils in the blood and lungs of patients with cystic fibrosis	Immunology-Inflammation	Clinical research	Germany	Prof. Dr. Dominik Hartl

Start date:	01/05/2013
End date:	31/06/2016
Status:	Ongoing
Researcher:	Prof. Dr. Leo Koendermann (Utrecht - The Netherlands)
Institute:	University of Tübingen
Department:	Department of Pediatrics I, Infectious Diseases & Immunology
City:	Tübingen
Project amount (€):	17.560

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Culture-independent analysis of bacterial communities for optimized diagnosis and treatment of patients with cystic fibrosis	Microbiology Screening and Diagnosis	Clinical research	Germany	Dr. Lutz von Müller

Start date:	01/09/2012
End date:	31/03/2016
Status:	Finished
Researcher:	Prof. Dr. Rober Bals (Homburg - Germany), Prof. Dr. Sebastian Suerbaum (Hannover - Germany), Prof. Dr. Burkhard Tümmler (Hannover - Germany)
Institute:	University Hospital of Saarland
Department:	Institute of Medical Microbiology and Hygiene
City:	Homburg
Project amount (€):	308.570

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Evaluation of an optical test system for the determination of the resistance profile of biofilm grown cystic fibrosis Pseudomonas aeruginosa isolates	Microbiology Screening and Diagnosis	Clinical research	Germany	Prof. Dr. Susanne Häußler

Start date:	01/07/2014
End date:	28/02/2016
Status:	Finished
Researcher:	Dr. Annette Sauer-Heilborn (Hannover - Germany)
Institute:	HelmTwincore, Centre for Experimental and Clinical Infection
Department:	Pathophysiology of Bacterial Biofilms
City:	Braunschweig
Project amount (€):	120.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Electrical Impedance Tomography guided patient-specific therapy decisions in Cystic Fibrosis related lung disease	Pulmonology Screening and Diagnosis	Clinical research	Germany	Prof. Dr. Knut Möller

Start date:	01/01/2018
End date:	31/06/2018
Status:	Ongoing
Institute:	University of Munich (LMU)
Department:	Institute of Technical Medicine
City:	Furtwangen
Project amount (€):	20.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Family coping and developmental issues: key factors for patient and family centered care in CF	Psychological issues	Clinical research	Germany	Prof. Dr. Andrea Heinzmann

Start date:	15/05/2017
End date:	14/05/2018
Status:	Ongoing
Institute:	University Hospital Freiburg
Department:	General Pediatrics, Pulmonology
City:	Freiburg
Project amount (€):	20.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Inhalable formulation for regulating cytokine secretion of alveolar macrophages modifying x-box-binding protein 1 expression as potential approach in CF treatment	New Therapies Immunology-Inflammation	Basic research	Germany	Prof. Dr. Mark Schneider

Start date:	01/03/2017
End date:	31/01/2018
Status:	Finished
Institute:	Saarland University
Department:	Pharmacy, Biopharmaceutics & Pharmaceutical Technology
City:	Saarbrücken
Project amount (€):	20.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Epigenetic Regulation of Resolution of Inflammation in Cystic Fibrosis	Immunology-Inflammation	Clinical research	Germany	Dr. Olaf Eickmeier

Start date:	01/01/2018
End date:	31/12/2018
Status:	Ongoing
Researcher:	Prof. Dr. Christopher Beermann (Fulda - Germany)
Institute:	J.W. Goethe - University of Frankfurt a. M.
Department:	Christiane Herzog CF Center
City:	Frankfurt
Project amount (€):	20.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Physiotherapy for Childen and Adolescents with Cystic Fibrosis – Getting an Overview on Current Practice	Psysiotherapy	Clinical research	Germany	Tina Hellmuth

Start date:	01/02/2018
End date:	31/01/2020
Status:	Ongoing
Institute:	Medical School Hannover
Department:	Pediatric Pulmonology - Allergology and Neonatology
City:	Hannover
Project amount (€):	4.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Effects of a partially supervised conditioning program in CF: an international, multi-centre, randomized controlled trial (Activate-CF)	Other Issues	Clinical research	Germany	Prof. Dr. Helge Hebestreit

Start date:	01/03/2014
End date:	31/07/2018
Status:	Ongoing
Researcher:	Dr. Susi Kriemler (Basel - Switzerland), Prof. Dr. Larry Lands (Montreal - Canada), Prof. Dr. David Orenstein (Pittsburgh - USA), Prof. Dr. Hiran Selvadurai (Sydney - Australia), Dr. Chantal Karila (Paris - France), Dr. Don Urquhart (Edinburgh - UK), Prof. Dr. Erik H. J. Hulzebos (Utrecht - The Netherlands)
Institute:	University Hospital Würzburg
Department:	Pediatrics
City:	Würzburg
Project amount (€):	240.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Rescue of F508del-CFTR mediated chloride secretion by mannosyl-glycoprotein-acetylglucosaminyl-transferases	CFTR Cell Biology	Basic research	Germany	Dr. Frauke Stanke

Start date:	01/04/2015
End date:	31/03/2018
Status:	Finished
Institute:	Medical School Hannover
Department:	Pediatric Pulmonology - Allergology and Neonatology
City:	Hannover
Project amount (€):	173.450

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Protease activity on the surface of airway inflammatory cells quantified by FRET sensors as novel non-invasive biomarkers for Cystic Fibrosis lung disease	Immunology-Inflammation	Basic research	Germany	Dr. Susanne Dittrich

Start date:	01/01/2017
End date:	21/12/2018
Status:	Ongoing
Researcher:	Dr. Carsten Schultz - Prof. Dr. Felix JF Herth - Dr. Mark O. Wielpütz
Institute:	University Hospital Heidelberg
Department:	Translational Pulmonology - Translational Lung Research Center (TLRC)
City:	Heidelberg
Project amount (€):	80.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
T cell epithelial crosstalk via IL-17A and IL-22 in CF lung disease	Immunology-Inflammation	Clinical research	Germany	Dr. Melanie Albrecht

Start date:	01/12/2016
End date:	30/11/2019
Status:	Ongoing
Institute:	Medical School Hannover
Department:	Pediatric Pulmonology - Allergology and Neonatology
City:	Hannover
Project amount (€):	70.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Drug Hypersensitivity in Cystic Fibrosis – development of diagnostic and management strategies	Antibiotics	Clinical research	Germany	Dr. Jobst Röhmel

Start date:	01/01/2018
End date:	31/12/2019
Status:	Ongoing
Institute:	Charité - Universitätsmedizin
Department:	Pediatric Pneumology and Immunology - Division of Cystic Fibrosis
City:	Berlin
Project amount (€):	95.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Investigation of the role of antimicrobial peptides in host defense and development of new strategies against pulmonary infection by Pseudomonas aeruginosa	Infection		France	Yongzheng Wu

Status:	Ongoing
City:	PARIS
Project amount (€):	65.004

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Etude des mécanismes moléculaires contrôlant l’activation de la NADPH-oxydase et la survie des neutrophiles dans la mucoviscidose: vers de nouvelles pistes thérapeutiques ciblées	Immunology-Inflammation		France	Véronique Witko-Sarsat

Status:	Ongoing
City:	PARIS
Project amount (€):	43.910

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Identification of Aspergillosis bronchitis/infection in cystic fibrosis patients based on antigen T-cell in vitro assays	Infection		France	Edouard Tuaillon

Status:	Ongoing
City:	MONTPELLIER
Project amount (€):	53.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Study of the implication of TRPM7 in CF	CFTR		France	Pascal Trouvé

Status:	Ongoing
City:	BREST
Project amount (€):	10.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Cystic fibrosis and microparticle-mediated cellular cross talk within the pancreas: Impact of infection and immunosuppressive drugs on insulin secretion and pancreatic cell fate	Pathogenesis		France	Florence Toti

Status:	Ongoing
City:	ILLKIRCH-GRAFFENSTADEN
Project amount (€):	20.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Determination of trans-acting elements that regulate the CFTR gene expression : microRNAs and transcription factors	Genetics		France	Magali Taulan

Status:	Ongoing
City:	MONTPELLIER
Project amount (€):	49.820

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Implication of miRNA in CF lung pathology: Studies of inflammation and ANO1 regulation by miRNAs	Immunology-Inflammation		France	Olivier Tabary

Status:	Ongoing
City:	PARIS
Project amount (€):	50.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Secreted Lipase A and Lipoxygenase A from P. aeruginosa: Potential targets to prevent chronic lung infection in cystic fibrosis	Infection		France	Mustapha Si Tahar

Status:	Ongoing
City:	TOURS
Project amount (€):	20.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Natural Killer immunity during CMV infection in the context of lung transplantation	Infection		France	Delphine Sauce

Status:	Ongoing
City:	PARIS
Project amount (€):	53.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Characterization of an endogeneous regulation of calcineurin contributing to the toxicity of calcineurin inhibitors	Transplantation		France	Sylvia Sanquer

Status:	Ongoing
City:	PARIS
Project amount (€):	35.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Proteases and CFTR : in vitro and in vivo regulation in lung epithelial cells and alveolar macrophages	Immunology-Inflammation		France	Jean-Michel Sallenave

Status:	Ongoing
City:	PARIS
Project amount (€):	65.004

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Continue the pilot study Lung transplantation from initially rejected donors after ex-vivo lung reconditioning	Transplantation		France	Edouard Sage

Status:	Ongoing
City:	SURESNES
Project amount (€):	103.481

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Functional studies on missense variations identified in CFTR pathologies: towards a better knowledge of the CFTR diseases	Genetics		France	Caroline Sabella

Status:	Ongoing
City:	MONTPELLIER
Project amount (€):	30.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Evaluation for antibiofilm activity of new Quorum Sensing inhibitors of Pseudomonas aeruginosa combined with antibiotics in a murine model of chronic lung infection.	Infection		France	Christine Roques

Status:	Ongoing
City:	TOULOUSE
Project amount (€):	58.004

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Prognostic impact of different cytotoxic mechanisms of Donor-Specific HLA class-I and -II Antibodies (DSA) in lung transplant recipients: Role of dependent complement activation and Antibody Dependant Cellular Cytotoxicity (ADCC)	Transplantation		France	Martine Reynaud-Gaubert

Status:	Ongoing
City:	MARSEILLE
Project amount (€):	32.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Prognostic value of clinical exercise testing in patients with cystic fibrosis	Atteinte pulmonaire		France	Anne Prévotat

Status:	Ongoing
City:	LILLE
Project amount (€):	30.800

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Nonsense mutation correction in CFTR gene in epithelial upper respiratory tract cells by chemical molecules	CFTR		France	Anne Prévotat

Status:	Ongoing
City:	LILLE
Project amount (€):	22.000

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Factors associated with a survival benefit of lung transplantation in patients with cystic fibrosis	Epidemiology		France	Raphaël Porcher

Status:	Ongoing
City:	PARIS
Project amount (€):	10.406

Project name:	Project category:	Kind of research:	Country:	Principle investigator:
Iminosugars acting as mannosidase inhibitors in misfolded diseases as Cystic Fibrosis: Design of multivalent correctors and identification of new therapeutically targets	CFTR		France	Caroline Norez

Status:	Ongoing
City:	POITIERS
Project amount (€):	20.000

Contact information

Hilde De Keyser
hilde.dekeyser@cf-europe.eu
0032 - (0)2 61 32 716

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