New insights into the lungs

VARIATION IN LUNG FUNCTION AND NUTRITIONAL DECLINE IN CYSTIC FIBROSIS BY GENOTYPE: AN ANALYSIS OF THE CANADIAN CYSTIC FIBROSIS REGISTRY

Authors: Garvin J. Leung1, Ting J. Cho2, Thomas Kovesi1,2,3, Jemila S. Hamid1,2, Dhenuka Radhakrishnan*1,2,3 Affiliations: 1 Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada 2 Children’s Hospital […]

 Read more

DISSOCATION OF SYSTEMIC AND MUCOSAL AUTOIMMUNITY IN CYSTIC FIBROSIS

Authors: Theprungsirikul, Ja, Skopelja-Gardner, Sa, Meagher, R. Ea, Clancy, J. Pb, Zemanick, E.Tc, Ashare, Aa,e, Rigby, W. F. Ca, d Affiliations: aDepartment of Microbiology and Immunology, Geisel School of Medicine […]

 Read more

SEASON IS ASSOCIATED WITH PSEUDOMONAS AERUGINOSA ACQUISITION IN YOUNG CHILDREN WITH CYSTIC FIBROSIS

Authors: Psoter KJ, DeRoos AJ, Wakefield J, Mayer J, Rosenfeld M.   What was your research question? The objectives of this study were to: (i) evaluate the seasonal acquisition of […]

 Read more

EARLY LIFE GROWTH TRAJECTORIES IN CYSTIC FIBROSIS ARE ASSOCIATED WITH PULMONARY FUNCTION AT AGE 6 YEARS

Authors: Sanders DB, Fink A, Mayer-Hamblett N, Schechter M, Sawicki GS, Rosenfeld M, Flume PA, Morgan WJ.   What was your research question? Is there a link between the severity […]

 Read more

SWATH LABEL-FREE PROTEOMICS FOR CYSTIC FIBROSIS RESEARCH

Authors: Clarissa Braccia1,4, Valeria Tomati2, Emanuela Caci2, Nicoletta Pedemonte2 and Andrea Armirotti3 Affiliations: 1D3Pharmachemistry, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy; 2U.O.C. Genetica Medica, IRCCS Istituto […]

 Read more

METHYLOMIC CORRELATES OF AUTOPHAGY ACTIVITY IN CYSTIC FIBROSIS

Authors: Kyle Caution1,8, Alexander Pan2,8, Kathrin Krause1,8, Asmaa Badr1,8, Kaitlin Hamilton1,8, Anup Vaidya1,8, Hawin Gosu1,8, Kylene Daily1,8, Shady Estfanous1,8, Mikhail A. Gavrilin5,8, Mark E. Drew1,8, Estelle Cormet-Boyaka3,8, Xi Chen3,8, David […]

 Read more

THE EFFECTS OF CYCLED INHALED AZTREONAM ON THE CYSTIC FIBROSIS (CF) LUNG MICROBIOME

Authors: Alya A. Heirali1; Nicole Acosta1; Douglas G. Storey1,2; Matthew L. Workentine3; Ranjani Somayaji1,4; Isabelle Laforest-Lapointe5,6, Winnie Leung7; Bradley S. Quon8; Yves Berthiaum9; Harvey R. Rabin1,4; Barbara J. Waddell1, Laura […]

 Read more

DEPLETION OF BAFF CYTOKINE EXACERBATES INFECTION IN PSEUDOMONAS AERUGINOSA INFECTED MICE

Authors: Dušan Garić1,4, Shao Tao2,4,Eisha Ahmed2,4, Mina Youssef1,4, Cynthia Kanagaratham1, 3, 4,Juhi Shah5, Bruce Mazer2, 4 and Danuta Radzioch1, 4 Affiliations: 1Department of Human Genetics, McGill University, Montreal, Quebec, Canada; […]

 Read more

MEASURING RECOVERY IN HEALT-RELATED QUALITY OF LIFE DURING AND AFTER PULMONARY EXACERBATIONS IN PATIENTS WITH CYSTIC FIBROSIS

Authors: Patrick A. Flume,a Ellison D. Suthoff,b Mark Kosinski,c Gautham Marigowda,d Alexandra L. Quittnere Affiliations: aMedical University of South Carolina, 96 Jonathan Lucas Street, 812-CSB, Charleston, SC 29425 USA; bFormerly […]

 Read more

PHYSICAL ACTIVITY AND ASSOCIATIONS WITH CLINICAL OUTCOME MEASURES IN ADULTS WITH CYSTIC FIBROSIS, A SYSTEMATIC REVIEW

Authors: James Shelley1, Lynne M Boddy1, Zoe R Knowles1, Claire E Stewart1, & Ellen A Dawson1. Affiliations: 1Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 […]

 Read more

CT EVALUATION OF HYPERATTENUATING MUCUS TO DIAGNOSE ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS IN THE SPECIAL CONDITION OF CYSTIC FIBROSIS

Authors: John Refait1, Julie Macey1,2,3, Stephanie Bui1, Michaël Fayon1,2,3, Patrick Berger1,2,3, Laurence Delhaes1,2,3, François Laurent1,2,3, Gaël Dournes1,2,3 Affiliations: 1CHU de Bordeaux, Service d’Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, […]

 Read more

3D PRINTING AND THE CYSTIC FIBROSIS LUNG

Authors: Alicia A Mirza, Terry E Robinson, Kyle Gifford, Haiwei Henry Guo Affiliations: Stanford University, Lucile Packard Children’s Hospital Stanford   What was your research question? Can 3D printing technology […]

 Read more

INTERLEUKIN-1 IS ASSOCIATED WITH INFLAMMATION AND STRUCTURAL LUNG DISEASE IN YOUNG CHILDREN WITH CYSTIC FIBROSIS

Authors: Samuel T. Montgomery1, A. Susanne Dittrich2,3, Luke W. Garratt4, Lidija Turkovic4, Dario L. Frey2,3, Stephen M. Stick1,4,5,6, Marcus A. Mall2,7,8, Anthony Kicic1,4,5,6,9, & AREST CF1,5,10,11. Affiliations: 1School of Paediatrics […]

 Read more

AGTR2 ABSENCE OR ANTAGONISM PREVENTS CYSTIC FIBROSIS PULMONARY MANIFESTATIONS

Authors: Rebecca J. Darrah1,2, Frank J. Jacono3,4, Neha Joshi5, Anna L. Mitchell2, Abdus Sattar6, Cara K. Campanaro3, Paul Litman1, Jennifer Frey2, David E. Nethery4, Eric S. Barbato1, Craig A. Hodges2,5, […]

 Read more

ELECTROCHEMICAL MEASUREMENT OF MEMBRANE CHOLESTEROL CORRELATES WITH CFTR FUNCTION AND IS HDAC6-DEPENDENT

Authors: Binyu Lu1, Li Li Molly Schneider2, Craig A. Hodges2, James A. Burgess3, and Thomas J. Kelley1,2 Affiliations: 1Department of Chemistry, Case Western Reserve University 2Department of Pediatrics, Case Western […]

 Read more

RESCUE OF CFTR NBD2 MUTANTS N1303K AND S1235R IS INFLUENCED BY THE FUNCTIONING OF THE AUTOPHAGOSOME

Authors: Qiangni Liu, Inna Sabirzhanova, Murali K. Yanda, Emily A.S. Bergbower, Clément Boinot, William B. Guggino, Liudmila Cebotaru Affiliations: Departments of Medicine and Physiology, Johns Hopkins University, Baltimore, MD, USA […]

 Read more

CONTINUOUS GLUCOSE MONITORING ABNORMALITIES IN CYSTIC FIBROSIS YOUTH CORRELATES WITH PULMONARY FUNCTION DECLINE

Authors: Christine L. Chan1, Timothy Vigers1, Laura Pyle1,2, Philip S. Zeitler1, Scott D. Sagel3, Kristen J. Nadeau1 Affiliations: 1Department of Pediatrics, Division of Pediatric Endocrinology, Children’s Hospital Colorado and University […]

 Read more

RESPIRATORY RATE IN INFANTS WITH CYSTIC FIBROSIS THROUGHOUT THE FIRST YEAR OF LIFE AND ASSOCIATION WITH LUNG CLEARANCE INDEX MEASURED SHORTLY AFTER BIRTH

Authors: Insa Korten1,2,3, Elisabeth Kieninger1, Sophie Yammine1, Giulia Cangiano4, Sylvia Nyilas1,2, Pinelopi Anagnostopoulou1, Florian Singer1, Claudia E. Kuehni5, Nicolas Regamey1,6, Urs Frey3, Carmen Casaulta1, Ben D. Spycher1,5, Philipp Latzin1 on […]

 Read more

RESISTIN IS ELEVATED IN CYSTIC FIBROSIS SPUTUM AND CORRELATES NEGATIVELY WITH LUNG FUNCTION

Authors: Osric A. Forrest1,2, Daniel M. Chopyk3, Yael Gernez4, Milton R. Brown1,2, Carol K. Conrad4, 6, Richard B. Moss4, Vin Tangpricha3,5, Limin Peng6, Rabindra Tirouvanziam1,2 Affiliations: 1Department of Pediatrics, Emory […]

 Read more

SHORT-TERM AND LONG-TERM RESPONSE TO PULMONARY EXACERBATION TREATMENT IN CYSTIC FIBROSIS

Authors: Heltshe SL, Goss CH, Thompson V, Sagel SD, Sanders DB, Marshall BC, Flume PA   What was your research question? We looked at differences in pulmonary exacerbation care in […]

 Read more

LUMACAFTOR/IVACAFTOR REDUCES PULMONARY EXACERBATIONS IN PATIENTS IRRESPECTIVE OF INITIAL CHANGES IN FEV1

Authors: Susanna A. McColley,a Michael W. Konstan,b Bonnie W. Ramsey,c J. Stuart Elborn,d Michael P. Boyle,e Claire E. Wainwright,f David Waltz,g Montserrat Vera-Llonch,g Gautham Marigowda,g John G. Jiang,g Jaime L. […]

 Read more

HUMAN EPIDIDYMIS PROTEIN 4 (HE4) LEVELS INVERSELY CORRELATE WITH LUNG FUNCTION IMPROVEMENT (DELTA FEV1) IN CYSTIC FIBROSIS PATIENTS RECEIVING IVACAFTOR TREATMENT

Authors: Béla Nagy Jr1, Zsolt Bene2, Zsolt Fejes1, Sonya L. Heltshe3, David Reid4, Nicola J. Ronan5, 3, Yvonne McCarthy5, Daniel Smith4, Attila Nagy6, Elizabeth Joseloff7, György Balla2,8, János Kappelmayer1, Milan […]

 Read more

HIGHER INTERLEUKIN-7 SERUM CONCENTRATIONS IN PATIENTS WITH CYSTIC FIBROSIS CORRELATES WITH IMPAIRED LUNG FUNCTION

Authors: Julia Seyfarth1, Sutharsan Sivagurunathan2, Sarah Ricken2, Gerhard Weinreich², Laura Olbrich1, Christian Taube², Ertan Mayatepek1, Dirk Schramm1, Marc Jacobsen1 Affiliations: 1 Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University […]

 Read more

GENOME-WIDE ASSOCIATION META-ANALYSIS IDENTIFIES FIVE MODIFIER LOCI OF LUNG DISEASE SEVERITY IN CYSTIC FIBROSIS

Citation: Corvol H, Blackman SM, Boëlle PY, et al. Nat Commun. 2015 Sep 29; 6:8382   What was your research question? What are non-cystic fibrosis transmembrane conductance regulator (CFTR) genes […]

 Read more

GENDER DIFFERENCES IN OUTCOMES OF PATIENTS WITH CYSTIC FIBROSIS

Citation: Harness-Brumley CL, Elliott AC, Rosenbluth DB, Raghavan D, Jain R.  Journal of Women’s Health. 2014 Dec; 23 (12): 1012-1020. PMID: 25495366   What was your research question? Does gender […]

 Read more

THE DYNAMICS OF DISEASE PROGRESSION IN CYSTIC FIBROSIS

Citation: Adler FR, Liou TG. PLOS ONE. 2016;11(6):e0156752.   What was your research question? How do lung function (FEV1%) and lung infections in CF interact and affect patient health and […]

 Read more

APPLICATION OF MULTIPLE EVENT ANALYSIS AS AN ALTERNATIVE APPROACH TO STUDYING PULMONARY EXACERBATIONS AS AN OUTCOME MEASURE

Authors: Elizabeth Juarez-Colunga1,2, Rosenfeld Margaret3, Edith T. Zemanick4, Brandie Wagner1,4 Affiliations: 1Department of Biostatistics and Informatics, University of Colorado School of Public Health, 2Adult and Child Consortium for Health Outcomes […]

 Read more

ABNORMAL PRESCHOOL LUNG CLEARANCE INDEX (LCI) REFLECTS CLINICAL STATUS AND PREDICTS LOWER SPIROMETRY LATER IN CHILDHOOD IN CYSTIC FIBROSIS

Authors: Hardaker KM1, Panda H2, Hulme K2, Wong A1, Coward E1, Cooper P1, Fitzgerald DA1,3, Pandit C1, Towns S1, Selvadurai H1,3, Robinson PD1,3. Affiliations: 1Department of Respiratory Medicine, The Children’s […]

 Read more

EARLY RESPIRATORY VIRAL INFECTIONS IN INFANTS WITH CYSTIC FIBROSIS

Authors: Ashley R Deschampa, Joseph E Hatchb, James E Slavenc, Netsanet Gebregziabherc, Gregory Storchd, Graham L. Halle, Stephen Stickf, Sarath Ranganathang,h,i, Thomas W Ferkold, Stephanie D Davisb Affiliations: aUniversity of […]

 Read more

ISOGENIC CELL MODELS OF CYSTIC FIBROSIS-CAUSING VARIANTS IN NATIVELY EXPRESSING PULMONARY EPITHELIAL CELLS

Authors: Hillary C. Valley1, Katherine M. Bukis1, Alisa Bell1, Yi Cheng1, Eric Wong1, Nikole J. Jordan1, Normand E. Allaire1, Andrey Sivachenko1, Feng Liang1, Hermann Bihler1, Philip J. Thomas1,2, Jerome Mahiou1, […]

 Read more

LUMACAFTOR-RESCUED F508DEL-CFTR HAS A MODIFIED BICARBONATE PERMEABILITY

Authors: Loretta Ferrera1, Debora Baroni2 and Oscar Moran2 Affiliations: 1Istituto Giannina Gaslini, U.O.C. Genetica Medica, Genova, Italy 2CNR, Istituto di Biofisica, Genova, Italy   What was your research question? The […]

 Read more

SYSTEMIC LEVELS OF ANTI-PAD4 AUTOANTIBODIES CORELATE WITH AIRWAY OBSTRUCTION IN CYSTIC FIBROSIS

Authors: Ruchi Yadav1, Dae-goon Yoo1, J. Michelle Kahlenberg2, S. Louis Bridges Jr3, Oluwadamilola Oni1, Hanwen Huang4, Arlene Stecenko5 and Balázs Rada1,6 Affiliations: 1Department of Infectious Diseases, College of Veterinary Medicine, […]

 Read more

NON-INVASIVE VENTILATION AND CLINICAL OUTCOMES IN CYSTIC FIBROSIS: FINDINGS FROM THE UK CF REGISTRY

Authors: Olga Archangelidi1, Siobhán B. Carr2, Nicholas J. Simmonds1,2, Diana Bilton1,2, Winston Banya1,2, Paul Cullinan1 on behalf of CF-EpiNet Affiliations: 1National Heart and Lung Institute, Imperial College London, 2Royal Brompton […]

 Read more

COMPARISON OF WHO AND CDC GROW CHARTS IN PREDICTING PULMONARY OUTCOMES IN CYSTIC FIBROSIS

Citation: Machogu E, Cao Y, Miller T, Simpson P, Levy H, Quintero D, Goday PS. J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):378-83.   What was your research question? The study evaluated […]

 Read more

GLYCOSAMINOGLYCANS ARE DIFFERENTIALLY INVOLVED IN BACTERIAL BINDING TO HEALTHY AND CYSTIC FIBROSIS LUNG CELLS

Authors: Carla Martina,b,c, Víctor Lozano-Iturbea,b,c, Rosa M. Girónd, Emma Vazquez-Espinosad, David Rodrigueze, Jesús Merayo-Llovesa,b, Fernando Vazqueza,b,c,f, Luis M. Quirósa,b,c and Beatriz Garcíaa,b,c Affiliations: aUniversity Institute Fernandez-Vega (IUFV), University of Oviedo […]

 Read more

COMPARISON OF LUNG CLEARANCE INDEX DETERMINED BY WASHOUT OF N2 AND SF6 IN INFANTS AND PRESCHOOL CHILDREN WITH CYSTIC FIBROSIS

Authors: Mirjam Stahla,b,c, Cornelia Joachima,b,c, Mark O. Wielpützc,d, and Marcus A. Malla,b,c,e,f Affiliations: aDivision of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Im […]

 Read more

SEASONAL FLUCTUATION OF LUNG FUNCTION IN CYSTIC FIBROSIS: A NATIONAL REGISTER-BASED STUDY IN TWO NORTHERN EUROPEAN POPULATIONS

Authors: Tavs Qvist1, Daniela K. Schlüter2, Vian Rajabzadeh3, Peter J. Diggle2, Tania Pressler1, Siobhán B. Carr4, David Taylor-Robinson5 Affiliations: 1Copenhagen Cystic Fibrosis Centre, Department of Infectious Diseases, Rigshospitalet, Copenhagen University, […]

 Read more

BASELINE ULTRASOUND AND CLINICAL CORRELATES IN CHILDREN WITH CYSTIC FIBROSIS

Authors: Leung DH, Ye W, Molleston JP, et al.   What was your research question? Is there a relationship between abnormal baseline research ultrasound findings and demographic and clinical features? […]

 Read more

EFFECT OF TREATMENT OF CYSTIC FIBROSIS PULMONARY EXACERBATIONS ON SYSTEMIC INFLAMMATION

Authors: Sagel SD, Thompson V, Chmiel JF, Montgomery GS, Nasr SZ, Perkett E, Saavedra MT, Slovis B, Anthony MM, Emmett P, Heltshe SL   What was your research question? We […]

 Read more

Contact information

Subscribe to newsletter